Exploring Piperacillin/Tazobactam Probability of Target Attainment (PTA) in Pseudomonas

Exploring pip/tazo PTA for Pseudomonas using popPK simulation. Key finds: 30-min infusions fall short of 90% PTA at MIC 16; prolonged infusion helps, but neutropenic fever population sees the biggest drop in PTA. ~46% of susceptible PsA isolates carry blaOXA-2 — tazobactam matters more than I thought

Motivations

We’ve learnt a bit …